The Donda artist was due to headline at the event in Indio, California, which begins next weekend.
The 44-year-old previously pulled out of Coachella 2020 before the festival was postponed as a result of the COVID-19 pandemic.
No reason has yet been given for West’s withdrawal, however, in February he threatened to cancel his Coachella set if fellow headliner Billie Eilish did not apologise for comments relating to Travis Scott.
The 20-year-old stated that she would “wait for people to be okay before I keep going”, after halting an Atlanta concert to help a struggling fan find an inhaler. Responding to the demand, Eilish said she was “just helping a fan” and “literally never said a thing about Travis.”
Scott was also scheduled to perform at Coachella 2022 before organisers cancelled his set following the Astroworld tragedy, where 10 people were killed in a crowd surge. Rumours had circulated that the goosebumps singer would make a return to the stage during West’s headline performance, however, this was never confirmed.
News of the cancellation comes amid weeks of erratic online behaviour, lashing out at his ex-wife Kim Kardashian and her new partner, Pete Davidson. West also came under fire after using a racial slur to describe TV host Trevor Noah, who had called out the rapper for “harassing” Kardashian and called his behaviour “terrifying to watch”.