Manfred made the announcement on Tuesday following days of negotiations between league officials and players in Florida.
“I am going to cancel some regular-season games. We worked hard to avoid an outcome that’s bad for our fans, bad for our players, and bad for our clubs,” he told reporters.
With no deal in place, Manfred says each team’s first two series of the regular season will not be played.
Additionally, players will not be paid for missed games and Manfred did not rule out future cancelations.
The Major League Baseball Players Association has since released statement saying it’s “disgusted” by Manfred’s decision to cancel games.
“As in the past, this effort will fail. We are united and committed to negotiating a fair deal that will improve the sport for Players, fans and everyone who loves our game,” MLBPA said.