He joins catcher Roberto Perez who is out with shoulder inflammation on his right shoulder and back spasms.
Cleveland went on to win the game 7-5 with Ramos replacement hitting a score-tying home runner.
The injury occurred during the seventh inning of the game after his left leg bucked and tore his knee ligaments.
He will now have to undergo surgery for the torn ACL and MCL, which will sideline him for the remainder of the season.
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